Nucleic acids encoding P-selectin ligand fusion proteins

US7927835B2 · kind B2 · utility

Assignee

• Genetics Institute, LLC · US

Inventors

• Glenn R. Larsen · Sudbury, US
• Dianne Sako · Medford, US
• Xiao-Jia Chang · Newton, US
• Geertruida M. Veldman · Sudbury, US
• Dale Cumming · Acton, US
• Ravindra Kumar · Cambridge, US
• Gray Shaw · Bedford, US

Key dates

• Filing date: Jul 3, 2008
• Grant date: Apr 19, 2011
• Expiry date: Jul 3, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/36222
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.