Alpha-galactosyl ceramide analogs and their use as immunotherapies
US7928077B2 · kind B2 · utility
39Cited by
2References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 11, 2008 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Mar 27, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.