Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US7928111B2 · kind B2 · utility
48Cited by
17References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 8, 2007 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Aug 8, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/566
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides compounds including substituted thienopyrimidinone derivatives of Formula (IIc) as ligands for modulating chemosensory receptors:These compounds are useful as sweet taste enhancers in comestible or medicinal compositions. The present invention also provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.