Nucleoside based proliferation imaging markers

US7928210B2 · kind B2 · utility

Assignee

• Siemens Medical Solutions USA, Inc. · US

Inventors

• Hartmuth C. Kolb · El Segundo, US
• Joseph C. Walsh · Santa Monica, US
• Robert Yeh · Gongguan, TW
• Kai Chen · Rockville, US
• Umesh B. Gangadharmath · Los Angeles, US
• Brian A. Duclos · Kalamazoo, US
• Vani P. Mocharla · Los Angeles, US
• Farhad Karimi · Mansfield, US
• Henry Clifton Padgett · Hermosa Beach, US
• Qianwa Liang · La Puente, US
• Tieming Zhao · Los Angeles, US

Key dates

• Filing date: Mar 3, 2008
• Grant date: Apr 19, 2011
• Expiry date: Jul 19, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/067
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.