Salts and polymorphs of a VEGF-R inhibitor

US7928226B2 · kind B2 · utility

Assignee

• Agouron Pharmaceuticals, Inc. · US

Inventors

• Yi Li · Shanghai, CN
• Jia Liu · San Diego, US
• Anand Sistla · Carlsbad, US
• Bruce J. Elder · Wynantskill, US
• Yufeng Hong · San Diego, US
• Paul K. Isbester · New York, US
• Grant J. Palmer · Clifton Park, US
• Jonathon S. Salsbury · Madison, US
• Luckner Ulysse · Albany, US

Key dates

• Filing date: Jul 27, 2006
• Grant date: Apr 19, 2011
• Expiry date: Jun 30, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to salts and free base forms of N,2-dimethyl-6-[7-(2-morpholinoethoxy)quinolin-4-yloxy]benzofuran-3-carboxamide. The invention further relates to pharmaceutical compositions of these salts and free base forms and methods of treating disorders such as cancer using such compositions.