Conversion of thebaine to morphine derivatives
US7928234B2 · kind B2 · utility
10Cited by
2References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2007 |
| Grant date | Apr 19, 2011 |
| Priority date | — |
| Expiry date | Oct 20, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides methods for the conversion of thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates of the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence of a metal catalyst.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.