Hepatitis B virus DNA polymerase and surface antigen variants and methods of using same
US7931907B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 6, 2008 |
| Grant date | Apr 26, 2011 |
| Priority date | — |
| Expiry date | Dec 1, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.