Macrocycle derivatives useful as inhibitors of β-secretase (BACE)

US7932261B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Ellen W. Baxter · Glenside, US
• François Paul Bischoff · Vosselaar, BE
• Hans Louis Jos De Winter · Schilde, BE
• Chih Yung Ho · Lansdale, US
• Yifang Huang · Cheltenham, US
• Michael H. Parker · Doylestown, US
• Allen B. Reitz · Lansdale, US
• Charles H. Reynolds · Austin, US
• Eric Strobel · Hatboro, US

Key dates

• Filing date: Feb 6, 2007
• Grant date: Apr 26, 2011
• Expiry date: Oct 30, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.