Imidazolidine carboxamide derivatives as P2X7 modulators
US7932282B2 · kind B2 · utility
1Cited by
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26Claims
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Key dates
| Filing date | Apr 2, 2008 |
| Grant date | Apr 26, 2011 |
| Priority date | — |
| Expiry date | Apr 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.