Process for preparing pyrrole derivatives and intermediates

US7932403B2 · kind B2 · utility

Assignee

• ratiopharm GmbH · DE

Inventors

• Pavel Bobal · Malacky, SK
• Jaroslav Frantisek · Brno, CZ
• Jiri Stohandl · Bobrová, CZ
• Kane Denike · Georgetown, CA
• Armin Boerner · Rostock, DE
• Vitali Tararov · Moscow, RU
• Andrei Korostylev · Ryazan, RU
• Gerd Koenig · Zwickau, DE
• Nicolas Jeker · Dornach, CH

Key dates

• Filing date: Dec 16, 2005
• Grant date: Apr 26, 2011
• Expiry date: Nov 5, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/738
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).