Patent · US Active

Antibodies to complementary peptides of thrombin or portions thereof

US7935341B2 · kind B2 · utility

1Cited by

4References

11Claims

0Family size

Assignee

Orthologic Corp. · US

Inventors

Darrell H. Carney · Dickinson, US
John Bergmann · Galveston, US
Gerald M. Fuller · Birmingham, US

Key dates

Filing date	Sep 14, 2006
Grant date	May 3, 2011
Priority date	—
Expiry date	Jul 6, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/75
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.