DNA sequence, and recombinant preparation of group 4 major allergens from cereals

US7935347B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Andreas Nandy · Hamburg, DE
• Helmut Fiebig · Schwarzenbek, DE
• Oliver Cromwell · Bad Nenndorf, DE

Key dates

• Filing date: Dec 1, 2004
• Grant date: May 3, 2011
• Expiry date: Nov 19, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the preparation of DNA sequences of group 4 major allergens from cereals. The invention also includes fragments, novel combinations of partial sequences and point mutations with hypoallergenic effects. The recombinant DNA molecules and the derived polypeptides, fragments, novel combinations of partial sequences and variants can be used for therapy of pollen-allergy diseases. The proteins produced by recombination can be applied to in-vitro and in-vivo diagnosis of pollen allergies.