Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

US7935819B2 · kind B2 · utility

Assignee

• AVENTIS PHARMA S.A. · FR

Inventors

• Frank Halley · Romford, GB
• Youssef El-Ahmad · Créteil, FR
• Victor CERTAL · Paris, FR
• Corinne Venot · Paris, FR
• Anne Dagallier · Paris, FR
• Hartmut Strobel · Liederbach, DE
• Kurt Ritter · Heidelberg, DE
• Sven Ruf · Mainz, DE

Key dates

• Filing date: Jul 15, 2008
• Grant date: May 3, 2011
• Expiry date: Aug 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I):wherein Ra, Rb, R, X1 and X2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are provided.