Patent · US Active

Purified recombinant batroxobin with high specific activity

US7939067B2 · kind B2 · utility

1Cited by

6References

9Claims

0Family size

Assignee

Shanghai Wanxing Biopharmaceuticals, Co., Ltd. · CN

Inventors

Xiudong Huang · Shanghai, CN
Peixin Chen · Shanghai, CN
Xuegong Pan · Shanghai, CN
Qiang Wang · Philadelphia, US
Zhifang Cao · Shanghai, CN

Key dates

Filing date	Sep 28, 2009
Grant date	May 10, 2011
Priority date	—
Expiry date	Sep 28, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A purified recombinant batroxobin with high specific activity, which has the following properties: (a) the batroxobin has a molecular weight of 29-32 kDa; (b) at least 90% of the batroxobin have 6 pairs of disulfide bonds which correctly match at Cys7-Cys139, Cys26-Cys42, Cys74-Cys230, Cys118-Cys184, Cys150-Cys163 and Cysl174-Cys199; (c) positions 146 and 225 in SEQ ID NO:1 are modified as N-glycosylation; and (d) the specific activity of the batroxobin is equal to or greater than 1500 KU/mg protein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.