Methods of identifying compounds that target tRNA splicing endonuclease and uses of said compounds as anti-proliferative agents
US7939468B2 · kind B2 · utility
0Cited by
20References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 8, 2010 |
| Grant date | May 10, 2011 |
| Priority date | — |
| Expiry date | Apr 8, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6897
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.