Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

US7939538B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Zice Fu · Foster City, US
• Michael G. Johnson · San Diego, US
• An-Rong Li · Mill Valley, US
• Andrew Marcus · Media, US
• Julio C. Medina · Redwood City, US
• Philippe Bergeron · San Francisco, US
• Xiaoqi Chen · Palo Alto, US
• Xiaohui Du · Foster City, US
• Jeffrey Deignan · San Francisco, US
• Jason A. Duquette · Millbrae, US
• Darin J. Gustin · Rue de l'Église, US
• Jeffrey T. Mihalic · San Francisco, US
• Jiwen Liu · Winston-Salem, US

Key dates

• Filing date: Jun 27, 2005
• Grant date: May 10, 2011
• Expiry date: Jul 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are provided having the formula:wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.