Process for preparing nitriles by elimination reactions

US7939688B2 · kind B2 · utility

Assignee

• Archimica, Inc. · US

Inventors

• Andreas Meudt · Hofheim, DE
• Sven Nerdinger · Birkenfeld, DE
• Claudius Boehm · Frankfurt, DE

Key dates

• Filing date: Jul 5, 2006
• Grant date: May 10, 2011
• Expiry date: Nov 27, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C253/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for preparing nitriles by reacting N-alkylcarboxamides (RCO—NHR1) or ammonium salts of carboxylic acids (RCOO—NH3R1+) or carboxylic acids in the presence of alkylamines or ammonium salts (RCOOH+NH2R1, RCOOH+NH3R1+), respectively, R being an arbitrarily substituted linear or branched C1-C12-alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl, alkynyl or aryl or heteroaryl radical and R1 being an arbitrary substituted, linear or branched C2-C1 alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl or alkynyl radical, with phosphonic anhydrides in the presence of an optional base in an organic solvent at a temperature in the range from −30 to 180° C. In advantageous embodiments, the phosphonic anhydride is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide of the formula (I)