Methods of generating a humoral immune response against human immunodeficiency virus (HIV) comprising administering Nef apoptotic motif-containing polypeptide-conjugates
US7943139B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Jan 7, 2005 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | Oct 31, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16334
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A small peptide of 10 or 11 mers, when linked to an immunogenic moiety, can protect against naferious effects of Nef protein of HIV. The vaccine is not used to induce sterilizing immunity, but to block the ability of soluble Nef protein to induce apoptosis, and to therefore alleviate lymphocyte depletion and organ damage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.