Platelet derived growth factor (PDGF)-derived neurospheres define a novel class of progenitor cells
US7943376B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Apr 25, 2002 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | Jul 15, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2503/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to the discovery of a novel class of neural progenitor cells, which proliferate in response to platelet derived growth factor (PDGF) and differentiate into neurons and oligodendrocytes but not astrocytes. Progeny of the progenitor cells can be obtained by culturing brain tissue in PDGF without serum, epidermal growth factor (EGF), fibroblast growth factor 2, or transforming growth factor alpha. Upon subculturing into EGF-containing media, these progeny cells can proliferate and form neurospheres, whereas PDGF has no such effect.
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