siRNA microbicides for preventing and treating diseases
US7943589B2 · kind B2 · utility
0Cited by
7References
17Claims
0Family size
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Inventors
Key dates
| Filing date | Jun 5, 2006 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | May 1, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.