Chiral fused [1,2]imidazo[4,5-C] ring compounds

US7943609B2 · kind B2 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• George W. Griesgraber · Eagan, US
• Tushar A. Kshirsagar · Woodbury, US
• Azim A. Celebi · Burlingame, US
• Sarah J. Slania · Eagan, US
• Michael E. Danielson · Windom, US
• Michael J. Rice · Oakdale, US
• Joshua R. Wurst · North St. Paul, US

Key dates

• Filing date: Dec 29, 2005
• Grant date: May 17, 2011
• Expiry date: Jun 17, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.