Btk protein kinase inhibitors
US7943618B2 · kind B2 · utility
15Cited by
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8Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 23, 2008 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | Oct 30, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application discloses pyridine and pyrimidine compounds according to formula I wherein R1,R2, R3, R4, R5, X1 and A are as described herein which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of formula I and at least one carrier, diluent or excipient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.