2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors
US7943649B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Oct 24, 2008 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | Dec 21, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses novel compounds of Formula Ior pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.