1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors

US7943654B2 · kind B2 · utility

Assignee

• NERVIANO MEDICAL SCIENCES S.R.L. · IT

Inventors

• Daniele Fancelli · Milano, IT
• Jurgen Moll · Tradate, IT
• Maurizio Pulici · Caponago, IT
• Francesca Quartieri · Borgomanero, IT
• Tizizno Bandiera · Cascina Portalupa, IT

Key dates

• Filing date: Jul 10, 2006
• Grant date: May 17, 2011
• Expiry date: Jan 30, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are provided thieno[2,3-c]pyrazole derivatives of formula (I), wherein A is an aryl or heteroaryl ring, on which the substituent-NHZR5 is at the ortho position to the CONH linker; R1 and R2 are the same or different and, independently from each other, represent a hydrogen atom or an organic group; R4 is a hydrogen or halogen atom or an organic group; Z is direct bond, >C═O, or —C(═O)NH—; R5 is hydrogen or an organic group; or isomers, tautomers, carriers, metabolites, prodrugs, and pharamaceutically acceptable salts thereof. A process for their preparation and pharamaceutical compositions comprising them are also disclosed; the compounds of the invention may be useful, in theraphy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.