Patent · US Active

Oligonucleotide analogs having cationic intersubunit linkages

US7943762B2 · kind B2 · utility

109Cited by
32References
16Claims
0Family size

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Key dates

Filing dateMay 10, 2007
Grant dateMay 17, 2011
Priority date—
Expiry dateAug 15, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2330/30
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Morpholino oligomers containing both uncharged and cationic intersubunit linkages are provided. The oligomers are oligonucleotide analogs containing predetermined sequences of base-pairing moieties. The presence of the cationic intersubunit linkages in the oligomers, typically at a level of about 10-50% of total linkages, provides enhanced antisense activity, in various antisense applications, relative to the corresponding uncharged oligomers. Also provided are such oligomers conjugated to peptide transporter moieties, where the transporters are preferably composed of arginine subunits, or arginine dimers, alternating with neutral amino acid subunits.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.