Hyperspectral microscope for in vivo imaging of microstructures and cells in tissues
US7945077B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 30, 2005 |
| Grant date | May 17, 2011 |
| Priority date | — |
| Expiry date | Jul 23, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/4792
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases or conditions causing alterations in cells and tissue micro structures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.