Drosophila cell lines producing recombinant secretable filovirus surface glycoproteins lacking the membrane spanning domain
US7947286B2 · kind B2 · utility
0Cited by
9References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 5, 2006 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Feb 8, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/14234
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Filovirus subunit protein immunogens are produced using a recombinant expression system and combined with one or more adjuvants in immunogenic formulations. The subunit proteins include GP95, GP-FL, VP40, VP24, and NP derived from Ebola Virus and Marburg Virus. Adjuvants include saponins, emulsions, alum, and dipeptidyl peptidase inhibitors. The disclosed immunogenic formulations are effective in inducing strong antibody responses directed against individual Filovirus proteins and intact Filovirus particles as well as stimulating cell-mediated immune responses to the Filoviruses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.