Methods and apparatus for characterizing polynucleotides

US7947454B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• The Regents of the University of California · US
• AGILENT TECHNOLOGIES, INC. · US

Inventors

• Mark A. Akeson · Santa Cruz, US
• Daniel Branton · Lexington, US
• David W. Deamer · Santa Cruz, US
• Jeffrey R. Sampson · San Jose, US

Key dates

• Filing date: Nov 25, 2009
• Grant date: May 24, 2011
• Expiry date: Nov 25, 2029

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0475
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.