Serpentine transmembrane antigens expressed in human cancers and uses thereof

US7947459B2 · kind B2 · utility

Assignee

• Latency, LLC · US

Inventors

• Rene S. Hubert · Los Angeles, US
• Arthur B. Raitano · Los Angeles, US
• Douglas Saffran · Los Angeles, US
• Daniel Afar · Santa Monica, US
• Steven Chappell Mitchell · Gurnee, US
• Mary Faris · Los Angeles, US
• Aya Jakobovits · Beverly Hills, US

Key dates

• Filing date: Jan 6, 2004
• Grant date: May 24, 2011
• Expiry date: Mar 3, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/705
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high'degree of structural conservation among them but show no significant structural homology to any known human proteins. STEAP-2 is a 454 amino acid protein characterized by a predicted molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops.