Methods for identifying agents that modulate LGIC receptor activity
US7947466B2 · kind B2 · utility
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2References
62Claims
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Inventors
Key dates
| Filing date | Sep 11, 2004 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Oct 17, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Fluorescence based screening assays are provided that allow for the for identification of agents that selectively bind to a ligand-gated ion channel (LGIC) such as a nicotinic acetylcholine receptor (nAChR). Also provided are methods for identifying agents that selectively bind to a neuronal-type nAChR by detecting binding of the agent to an Aplysia AChBP, which is representative of a neuronal-type nAChR. In addition, compositions and kits for performing such methods are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.