Liquid buffered GDF-5 formulations
US7947649B2 · kind B2 · utility
8Cited by
66References
14Claims
0Family size
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Key dates
| Filing date | Apr 8, 2009 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Apr 26, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein the solution has a pH of from about 4.2 to about 5.3, thereby providing for a biologically isotonic solution having improved stability of the GDF-5 protein during storage, handling, and use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.