Ansamycin formulations and methods of use thereof

US7947670B2 · kind B2 · utility

Assignee

• Infinity Pharmaceuticals, Inc. · US

Inventors

• Brian C. Austad · Tewksbury, US
• Louis Grenier · Medford, US
• Edward Holson · Newton, US
• John J. Lee · Somerville, US
• Roger H. Pak · Boxborough, US
• James R. Porter · Rowley, US
• James L. Wright · Springfield, US

Key dates

• Filing date: Dec 11, 2007
• Grant date: May 24, 2011
• Expiry date: Mar 29, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D225/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 (“Hsp90”).