Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3)
US7947807B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Sep 19, 2008 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Dec 2, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.