Radiolabelled benzamide analogues, their synthesis and use in diagnostic imaging
US7947838B2 · kind B2 · utility
2Cited by
6References
8Claims
0Family size
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Key dates
| Filing date | Dec 21, 2009 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Dec 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
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