Plant and plant storage organ having GLP-1 derivative accumulated therein and method of producing the same
US7947876B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 14, 2004 |
| Grant date | May 24, 2011 |
| Priority date | — |
| Expiry date | Mar 11, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8257
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is regarding plants and plant storage organs thereof in which GLP-1 derivatives are accumulated, and methods of producing them. The transgenic plants and plant storage organs thereof accumulate tandem repeated GLP-1 derivatives cleavable with intestinal digestive enzyme to monomeric molecules and are produced by methods comprising: integrating into vectors linked DNAs which comprise tandem repeated DNAs encoding the GLP-1 derivative with trypsin resistance in which the amino acid in the 26th position is Gln, the amino acid in the 34th position is Asn or Asp, and C-terminal consists of Arg or Lys to produce monomeric molecules; introducing the vectors into plant cells; and redifferentiating the obtained transformants. The edible transgenic plants and plant storage organs are useful for treating diabetes and can be ingested by diabetic patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.