Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant
US7951378B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 28, 2001 |
| Grant date | May 31, 2011 |
| Priority date | — |
| Expiry date | Apr 28, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/32722
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The immunoadhesions of the present invention are useful in treating rhinovirus infections. The immunoadhesions contain a chimeric ICAM molecule and may optionally also contain J chain and secretory compounds. The chimeric ICAM molecule is a fusion protein that has a rhinovirus receptor protein linked to an immunoglobulin protein. This invention also includes the greatly increased and improved method of producing immunoadhesions in plants. Each of the components of an immunoadhesin is produced in a plant cell and thereby assembles within the plant cell. This method of producing the immunoadhesions of the present invention results in the efficient and economic production of these molecules. The present invention also contemplates the production of immunoadhesions in a variety of eukaryotic cells including plants and mammalian cells. The immunoadhesions of the present invention are useful as a therapeutic against the common cold in humans which is caused by rhinoviruses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.