Hollow nanoparticle of NBsAg large protein for drug delivery
US7951379B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 26, 2003 |
| Grant date | May 31, 2011 |
| Priority date | — |
| Expiry date | Oct 21, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/859
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein that has been modified to lack its infectivity to hepatocytes and display an antibody). The particle surface of the drug displays an antibody, such as a cancer specific antibody, that recognizes an antigen molecule displayed on the surface of a specific cancer cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.