Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US7951549B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 2009 |
| Grant date | May 31, 2011 |
| Priority date | — |
| Expiry date | Mar 9, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/525
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides tumor cell preparations for use as models of the EMT process for use in the identification of anti-cancer agents, wherein said tumor cell preparations comprise cells of the epithelial tumor cell line H358, which are stimulated by receptor ligands to induce EMT, or which have been engineered to inducibly express a protein that stimulates EMT. The present invention also provides methods of identifying potential anti-cancer agents by using such tumor cell preparations to identify agents that inhibit EMT, stimulate MET, or inhibit the growth of mesenchymal-like cells. Such agents should be particularly useful when used in conjunction with other anti-cancer drugs such as EGFR and IGF-1R kinase inhibitors, which appear to be less effective at inhibiting tumor cells that have undergone an EMT.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.