Method for bacteriophage delivery and amplification

US7951579B2 · kind B2 · utility

Assignees

• Board of Trustees of the University of Arkansas · US
• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Billy Hargis · Fayetteville, US
• Stacy E. Higgins · Fayetteville, US
• Lisa Bielke · Wooster, US
• Guillermo I. Tellez · Fayetteville, US
• Lisa A. Newberry · Bentonville, US
• Gerardo Nava · Urbana, US
• Ann M. Donoghue · Springdale, US
• Daniel Donoghue · Oregon, US

Key dates

• Filing date: Jun 23, 2006
• Grant date: May 31, 2011
• Expiry date: May 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2795/10232
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.