Patent · US Active

Mass defect labeling and methods of use thereof

US7951602B2 · kind B2 · utility

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8Claims
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Key dates

Filing dateAug 28, 2007
Grant dateMay 31, 2011
Priority date—
Expiry dateFeb 21, 2029

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10T436/24
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Mass defect labeled peptides and methods of identifying peptides are provided. In particular, embodiments of the present disclosure include mass defect labels for polypeptides that include at least one cysteine and/or at least one tryptophan and methods of using the mass defect labels to identify polypeptides. One embodiment, among others, includes a mass defect labeled peptide including at least one cysteine residue labeled with 2,4-dibromo-acetanilide. Another embodiment, among others, includes a mass defect labeled peptide including at least one tryptophan residue labeled with 4,6-dibromo-2-trifluoromethylphenylsulfenyl chloride.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.