Chaperonin 10 modulation of toll-like receptor-inducible cytokine and chemokine secretion

US7951613B2 · kind B2 · utility

Assignee

• CBIO LIMITED · AU

Inventors

• Barbara Jane Johnson · Calle de la Era, AU
• Andreas Suhrbier · Brisbane, AU
• Dean Jason Naylor · Forsayth, AU
• Caroline Amanda Dobbin · Brisbane, AU
• Christopher Bruce Howard · Calle de la Era, AU

Key dates

• Filing date: Sep 3, 2009
• Grant date: May 31, 2011
• Expiry date: Sep 3, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.