Phosphoramidate compounds and methods of use
US7951787B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Jul 20, 2004 |
| Grant date | May 31, 2011 |
| Priority date | — |
| Expiry date | Jul 25, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.