Quinazolinedione derivatives as TRPA1 modulators

US7951814B2 · kind B2 · utility

Assignee

• Glenmark Pharmaceuticals S.A. · CH

Inventors

• Meyyappan Muthuppalniappan · Hyderabad, IN
• Abraham Thomas · Jamkhed, IN
• Sukeerthi Kumar · Navi Mumbai, IN
• Sanjay Margal · Navi Mumbai, IN
• Neelima Khairatkar-Joshi · Thane, IN
• Indranil Mukhopadhyay · Navi Mumbai, IN
• Srinivas Gullapalli · Navi Mumbai, IN

Key dates

• Filing date: Jun 16, 2009
• Grant date: May 31, 2011
• Expiry date: Jun 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.