Glycopegylated granulocyte colony stimulating factor
US7956032B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 2005 |
| Grant date | Jun 7, 2011 |
| Priority date | — |
| Expiry date | Oct 21, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/193
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.