Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases

US7956185B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Robert Bruce Diebold · Waukegan, US
• Stevan W. Djuric · Libertyville, US
• Vincent L. Giranda · Gurnee, US
• Laura Hexamer · Grayslake, US
• Nan-Horng Lin · Mundelein, US
• Julie M. Miyashiro · Skokie, US
• Thomas D. Penning · Elmhurst, US
• Magdalena Przytulinska · Chicago, US
• Thomas J. Sowin · Grayslake, US
• Gerard M. Sullivan · Round Lake Beach, US
• Zhi-Fu Tao · Vernon Hills, US
• Yunsong Tong · Libertyville, US
• Anil Vasudevan · Union Grove, US
• Le Wang · Xi'an, CN
• Keith W. Woods · Lincolnshire, US
• Zhiren Xia · Gurnee, US
• Henry Zhang · Grayslake, US

Key dates

• Filing date: May 24, 2007
• Grant date: Jun 7, 2011
• Expiry date: May 24, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula (I)where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.