Maleate, tosylate, fumarate and oxalate salts of 5-(1-(S)-amino-2-hydroxyethyl)-N-[(2,4-difluorophenyl)-methy]-2-[8-methoxy-2-(triflouromethy)-5-quinoline]-4-oxazolecarboxamide and preparation process therefore

US7956189B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Xiaoming Chen · Xi'an, CN
• Xiao-Tao Chen · New York, US
• Jianguo Yin · Plainsboro, US
• Xiaoyong Fu · Edison, US
• David J. Blythin · North Caldwell, US
• Rongze Kuang · Green Brook, US
• Ho-Jane Shue · Pine Brook, US
• Scott Trzaska · Raritan, US
• Chee-Wah Tang · Singapore, SG
• Vincenzo Liotta · Glen Ridge, US
• Zaher Shabani · Budd Lake, US

Key dates

• Filing date: Aug 10, 2007
• Grant date: Jun 7, 2011
• Expiry date: Dec 23, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are maleate, tosylate, fumarate, and oxalate salts of the compound 5-(1(S)-Amino-2-Hydroxyethyl)-N-[(2,4-Difluorophenyl)-Methyl]-2-[8-Methoxy-2-(Trifluoromethyl)-5-Quinoline]-4-Oxazolecarboxamide, represented by Formula I, and methods of preparing the same.