1,3-dihydro-benzimidazol-2-ylidene amines as inhibitors of respiratory syncytial virus replication
US7956196B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 17, 2006 |
| Grant date | Jun 7, 2011 |
| Priority date | — |
| Expiry date | May 1, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formulathe addition salts and stereochemically isomeric forms wherein each Alk is C1-6alkanediyl; Q is hydrogen; C1-6alkyl substituted with one or two Ar2 radicals; C1-6alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar2; or Q is a radical of formulawherein t is 1, 2 or 3; R4 is amino, mono-or di(C1-6alkyl)amino; wherein R6 is hydrogen, C1-6alkyl, substituted C1-6alkyl; R7, R8, R9 are halo, cyano, C1-6alkyl, substituted C1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, C2-6alkynyl, cyanoC2 6alkynyl, Ar1, R10a—0—, R10a—S—, —N(R5aR5b), R10a—O—C(═O)—, N(R5aR5b)—C(═O)—, R10a—C(═O)—NR5b—, R10b—C(═O)—O—; and R8 and/or R9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.