Patent · US Active

Alpha-helical mimetics

US7956216B2 · kind B2 · utility

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2References

28Claims

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Assignee

THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

Guillaume Laurent Lessene · Melbourne, AU
Jonathan Bayldon Baell · Ivanhoe, AU

Key dates

Filing date	Dec 21, 2006
Grant date	Jun 7, 2011
Priority date	—
Expiry date	Aug 22, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/14
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.