Tumor cytotoxicity induced by modulators of the CXCR4 receptor
US7960346B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Nov 5, 2007 |
| Grant date | Jun 14, 2011 |
| Priority date | — |
| Expiry date | Jan 14, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.