Bivalent Smac mimetics and the uses thereof

US7960372B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Haiying Sun · Ann Arbor, US
• Dongguang Qin · Auburn Hills, US
• Zaneta Nikolovska-Coleska · Ann Arbor, US
• Jianfeng Lu · Ann Arbor, US
• Su Qiu · Ann Arbor, US
• Yuefeng Peng · Ann Arbor, US
• Qian Cai · Ann Arbor, US

Key dates

• Filing date: May 4, 2007
• Grant date: Jun 14, 2011
• Expiry date: Mar 12, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.